EDAN H99S with NRBC & RET 6‑Part Hematology Analyzer

The EDAN H99S is a premium 6‑part differential hematology analyzer built on an advanced fluorescent 3D flow cytometry platform. Designed for mid‑ to high‑volume clinical laboratories, it delivers precise CBC and differential analysis with fully standardized workflows and a throughput of up to 100 tests per hour.

The H99S represents the fully‑equipped flagship of the H90 series, combining the true 6‑part differential with fully validated Immature Granulocytes (IG) , automated NRBC reporting in every CBC test, and an integrated RET (reticulocyte) channel as a standard feature. This comprehensive solution delivers the broadest clinical insights—from infection and inflammation assessment to advanced anemia and thrombopoiesis management.

Key Features & Benefits

True 6‑Part Differential with Immature Granulocytes

The H99S goes beyond traditional 5‑part differentials by providing a true 6‑part differential that includes Immature Granulocytes (IG) with full validation. The six WBC subpopulations reported are:

• Neutrophils (NEU) – key indicator of bacterial infection

• Lymphocytes (LYM) – essential for viral infection and immune status

• Monocytes (MON) – elevated in chronic inflammation

• Eosinophils (EOS) – critical for allergy and parasitic infection detection

• Basophils (BAS) – valuable for allergic reactions

• Immature Granulocytes (IG) – the sixth population, providing early warning of infection, inflammation, or bone marrow response

This expanded differential enables earlier detection of left shift and more comprehensive assessment of hematological status.

Automated NRBC Reporting – No Extra Steps, No Extra Cost

The H99S reports Nucleated Red Blood Cells (NRBCs) in every CBC test with no additional steps, reagents, or operator intervention required. NRBC results are reportable and do not require WBC correction—streamlining routine workflows while preventing falsely elevated WBC and lymphocyte counts caused by undetected NRBCs.

Integrated RET Channel – Standard on the H99S

The H99S comes with the RET (reticulocyte) channel as a standard feature, providing comprehensive indices for advanced anemia assessment and treatment monitoring:

• IRF (Immature Reticulocyte Fraction) – indicator of reticulocyte production

• RHE (Reticulocyte Hemoglobin Equivalent) – assesses iron incorporation into hemoglobin

• IPF (Immature Platelet Fraction) – a direct cellular indicator of thrombopoietin activity

• LFR/MFR/HFR – reticulocyte maturation fractions providing a basis for anemia diagnosis and detection

• InR (Infected RBC) – assists in malaria screening

These advanced indices provide deeper insights into erythropoiesis, iron metabolism, and platelet production.

Fluorescent 3D Flow Cytometry Technology

The H99S utilizes fluorescent 3D analysis combining forward scatter, side scatter, and side fluorescence to assess cell size, morphology, and nucleic‑acid content. This multi‑parameter approach ensures:

• Precise WBC measurement with excellent performance for 5‑part and 6‑part differentials

• Enhanced and optimized flagging for left shift, atypical/abnormal lymphocytes, and blasts

• Accurate RET, DIFF, and NRBC results

Comprehensive Platelet Solution

The H99S offers a multi‑technology approach to platelet counting:

• PLT‑I – improved impedance‑based platelet counting

• PLT‑O – optical fluorescent platelet counting

• PLT‑A – AI‑driven Smart Computing

This combination resolves most interferences including RBC fragments, microcytes, and platelet clumps, while improving low‑count accuracy.

Expanded RBC Indices

Beyond standard RBC parameters, the H99S provides advanced indices for anemia and infection screening, supporting more comprehensive patient assessment.

High Throughput & Flexible Sampling

• Throughput: Up to 100 tests per hour

• Sample Volume: As low as 23 μL

• Sample Modes: Venous, capillary, and pre‑diluted

• Front‑back sheath flow eliminates secondary dilution, improving counting accuracy and reducing clogging

Smart Workflow Automation

• Barcode Entry QC for secure, simple QC sheet scanning

• Efficient Repeat, Rerun, and Reflex rules based on your criteria

• Enhanced customizable printout formats

• Load and Go operation for maximum efficiency

• Intuitive upgraded UI with robust data management software for storing, reviewing, and exporting results

Longer Reagent Stability

The H99S features extended reagent shelf life to reduce waste and operating costs:

RFID Reagent Management

Single‑use RFID ensures reagent authenticity and traceability, securing your reagent business model and preventing errors.

Versatile Functionality

The H99S is designed for versatility, making it an ideal solution for a wide range of users, from mid‑ to high‑volume labs.

Technical Specifications

Why Choose the EDAN H99S?