Molecision S6 Digital PCR System #

Product Overview

The Molecision S6 is a fully integrated digital PCR (dPCR) system that leverages third-generation PCR technology to achieve absolute quantification without the need for standard curves. Unlike traditional dPCR systems, the Molecision S6 combines droplet generation, PCR amplification, signal reading, and data analysis into a single, enclosed analyzer. This all-in-one design significantly reduces manual handling, minimizes contamination risks, and streamlines your workflow, making precise genetic quantification more accessible than ever.

Key Features

• Fully Integrated, Enclosed System: Combines droplet generation, PCR amplification, droplet reading, and data analysis in one analyzer for complete automation. The closed system design minimizes contamination risk and reduces hands-on time.

• Rapid Detection: Detection speed of 2–4 seconds per channel, with total run time of just 2.5 hours.

• High-Throughput Capability: Supports 16 samples per run with 4 independent ddPCR chips in a 4×4 configuration.

• Multiplexing Capability: 5 fluorescence channels (FAM, HEX, ROX, CY5, and CY5.5) enable simultaneous detection of multiple genes in a single reaction.

• Superior Droplet Generation: Generates over 25,000 droplets per sample with droplet volume less than 0.8 nL. Excellent droplet uniformity and thermal stability (CV < 5%) with generation efficiency exceeding 95%.

• Exceptional Performance:

  • High Sensitivity: Detects targets as low as 0.01%.

  • High Precision: Precision within ±10%.

  • Wide Dynamic Range: Linear dynamic range covering 5 logs.

• Customized Reagents: Supports reagent development using specialized Master Mix to meet diverse testing needs.

Technical Specifications

Reagent and Consumables

The Molecision S6 system is designed for ease of use and reliability, supported by high-quality consumables and flexible reagent options.

ddPCR Chips

• Ready-to-use chips designed for seamless integration with the Molecision S6 system.

• Generate >25,000 uniform droplets per sample with excellent thermal stability.

• Droplet generation efficiency >95% with uniformity CV <5%.

Customized Reagents

• Supports the development of customized reagents using specialized Master Mix.

• Flexible to meet different customer requirements for a wide range of applications.

Test Menu

The Molecision S6 is a versatile digital PCR platform suitable for a broad range of absolute quantification applications. Common test categories include:

Oncology

• Liquid biopsy (circulating tumor DNA detection)

• Rare mutation detection (e.g., EGFR, KRAS, BRAF)

• Copy number variation (CNV) analysis

• Minimal residual disease (MRD) monitoring

Infectious Disease

• Viral load quantification (e.g., HBV, HCV, HIV, CMV)

• Pathogen detection and absolute quantification

• Transplant monitoring (e.g., BK virus, CMV)

Genetic Testing

• Gene expression analysis

• MicroRNA quantification

• Carrier screening

Research Applications

• Gene editing validation (CRISPR)

• Absolute quantification of nucleic acids

• Environmental and food safety testing

Why Choose Molecision S6?

• True Sample-to-Answer Solution: A fully integrated, enclosed system that automates the entire digital PCR workflow—from droplet generation to data analysis.

• Minimize Contamination: The closed system design reduces the risk of carryover contamination, ensuring reliable and reproducible results.

• Save Time and Labor: With only 2.5 hours total run time and minimal manual intervention, the system streamlines your laboratory workflow.

• High Multiplexing: 5 fluorescence channels allow simultaneous detection of multiple targets in a single sample.

• Excellent Performance: High sensitivity (0.01%), high precision (±10%), and wide dynamic range (5 logs) deliver accurate absolute quantification for challenging applications.

• Customizable: Support for reagent development enables flexibility to meet both routine testing and unique research requirements.

• High-Quality Consumables: ddPCR chips provide consistent droplet generation and thermal stability, ensuring reliable performance.